PharmacyCodes



Fomepizolum [INN-Latin] en es it fr

Fomepizolum [INN-Latin] Brand names, Fomepizolum [INN-Latin] Analogs

Fomepizolum [INN-Latin] Brand Names Mixture

  • No information avaliable

Fomepizolum [INN-Latin] Chemical_Formula

C4H6N2

Fomepizolum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic/antizol.htm

Fomepizolum [INN-Latin] fda sheet

Fomepizolum [INN-Latin] msds (material safety sheet)

Fomepizolum_[INN-Latin] MSDS

Fomepizolum [INN-Latin] Synthesis Reference

No information avaliable

Fomepizolum [INN-Latin] Molecular Weight

82.1039 g/mol

Fomepizolum [INN-Latin] Melting Point

25 oC

Fomepizolum [INN-Latin] H2O Solubility

No information avaliable

Fomepizolum [INN-Latin] State

Liquid

Fomepizolum [INN-Latin] LogP

0.82

Fomepizolum [INN-Latin] Dosage Forms

Liquid

Fomepizolum [INN-Latin] Indication

Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis

Fomepizolum [INN-Latin] Pharmacology

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate. It is glycolate and oxalate that are primarily responsible for the metabolic acidosis and renal damage that are seen in ethylene glycol poisoning. {01}{03} Methanol is first metabolized to formaldehyde and then undergoes subsequent oxidation via formaldehyde dehydrogenase to become formic acid. It is formic acid that is primarily responsible for the metabolic acidosis and visual disturbances that are associated with methanol poisoning.

Fomepizolum [INN-Latin] Absorption

Rapid and complete

Fomepizolum [INN-Latin] side effects and Toxicity

Headache, nausea, dizziness

Fomepizolum [INN-Latin] Patient Information

Fomepizolum [INN-Latin] Organisms Affected

Humans and other mammals