Fluvastatin
Fluvastatin Brand names, Fluvastatin Analogs
Fluvastatin Brand Names Mixture
- No information avaliable
Fluvastatin Chemical_Formula
C24H26FNO4
Fluvastatin RX_link
http://www.rxlist.com/cgi/generic2/fluvastatinxl.htm
Fluvastatin fda sheet
Fluvastatin msds (material safety sheet)
Fluvastatin Synthesis Reference
F. G. Kathawala, U.S. Pat. 4,739,073 (1988)
Fluvastatin Molecular Weight
411.466 g/mol
Fluvastatin Melting Point
194-197oC
Fluvastatin H2O Solubility
0.46 mg/L
Fluvastatin State
Solid
Fluvastatin LogP
4.98
Fluvastatin Dosage Forms
Capsules; Tablets (extended-release)
Fluvastatin Indication
For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia
Fluvastatin Pharmacology
Fluvastatin, the first synthetically-prepared HMG-CoA reductase inhibitor, is used as an antilipemic to lower cholesterol and triglyceride levels associated with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb) and to slow the progression of coronary atherosclerosis in patients with coronary artery disease. Although similar to lovastatin, simvastatin, and pravastatin, Fluvastatin has a shorter half-life, no active metabolites, extensive protein binding, and minimal CSF penetration.
Fluvastatin Absorption
24% (range 9%-50%).
Fluvastatin side effects and Toxicity
Variety of GI complaints and an increase in transaminase values (i.e., SGOT and SGPT).
Fluvastatin Patient Information
PATIENT INFORMATION
Patients should be advised to report promptly unexplained muscle pain, tenderness or
weakness, particularly if accompanied by malaise or fever.
Women should be informed that if they become pregnant while receiving Lescol or Lescol
XL the drug should be discontinued immediately to avoid possible harmful effects on a
developing fetus from a relative deficit of cholesterol and biological products derived
from cholesterol. In addition, Lescol or Lescol XL should not be taken during nursing.
Patients should be advised to report promptly unexplained muscle pain, tenderness or
weakness, particularly if accompanied by malaise or fever.
Women should be informed that if they become pregnant while receiving Lescol or Lescol
XL the drug should be discontinued immediately to avoid possible harmful effects on a
developing fetus from a relative deficit of cholesterol and biological products derived
from cholesterol. In addition, Lescol or Lescol XL should not be taken during nursing.
Fluvastatin Organisms Affected
Humans and other mammals
