Lescol
Lescol Brand names, Lescol Analogs
Lescol Brand Names Mixture
- No information avaliable
Lescol Chemical_Formula
C24H26FNO4
Lescol RX_link
http://www.rxlist.com/cgi/generic2/fluvastatinxl.htm
Lescol fda sheet
Lescol msds (material safety sheet)
Lescol Synthesis Reference
F. G. Kathawala, U.S. Pat. 4,739,073 (1988)
Lescol Molecular Weight
411.466 g/mol
Lescol Melting Point
194-197oC
Lescol H2O Solubility
0.46 mg/L
Lescol State
Solid
Lescol LogP
4.98
Lescol Dosage Forms
Capsules; Tablets (extended-release)
Lescol Indication
For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia
Lescol Pharmacology
Fluvastatin, the first synthetically-prepared HMG-CoA reductase inhibitor, is used as an antilipemic to lower cholesterol and triglyceride levels associated with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb) and to slow the progression of coronary atherosclerosis in patients with coronary artery disease. Although similar to lovastatin, simvastatin, and pravastatin, Fluvastatin has a shorter half-life, no active metabolites, extensive protein binding, and minimal CSF penetration.
Lescol Absorption
24% (range 9%-50%).
Lescol side effects and Toxicity
Variety of GI complaints and an increase in transaminase values (i.e., SGOT and SGPT).
Lescol Patient Information
PATIENT INFORMATION
Patients should be advised to report promptly unexplained muscle pain, tenderness or
weakness, particularly if accompanied by malaise or fever.
Women should be informed that if they become pregnant while receiving Lescol or Lescol
XL the drug should be discontinued immediately to avoid possible harmful effects on a
developing fetus from a relative deficit of cholesterol and biological products derived
from cholesterol. In addition, Lescol or Lescol XL should not be taken during nursing.
Patients should be advised to report promptly unexplained muscle pain, tenderness or
weakness, particularly if accompanied by malaise or fever.
Women should be informed that if they become pregnant while receiving Lescol or Lescol
XL the drug should be discontinued immediately to avoid possible harmful effects on a
developing fetus from a relative deficit of cholesterol and biological products derived
from cholesterol. In addition, Lescol or Lescol XL should not be taken during nursing.
Lescol Organisms Affected
Humans and other mammals
