Finasteridum [Inn-Latin]
Brand names,
Finasteridum [Inn-Latin]
Analogs
Finasteridum [Inn-Latin]
Brand Names Mixture
Finasteridum [Inn-Latin]
Chemical_Formula
C23H36N2O2
Finasteridum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic3/propecia.htm
Finasteridum [Inn-Latin]
fda sheet
Finasteridum [Inn-Latin]
msds (material safety sheet)
Finasteridum [Inn-Latin]
Synthesis Reference
No information avaliable
Finasteridum [Inn-Latin]
Molecular Weight
372.544 g/mol
Finasteridum [Inn-Latin]
Melting Point
252-254 oC
Finasteridum [Inn-Latin]
H2O Solubility
11.7 mg/L
Finasteridum [Inn-Latin]
State
Solid
Finasteridum [Inn-Latin]
LogP
4.277
Finasteridum [Inn-Latin]
Dosage Forms
Tablet
Finasteridum [Inn-Latin]
Indication
For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: Improve symptoms, reduce the risk of acute urinary retention, reduce the risk of the need for surgery including transurethral resection of the prostat.
Finasteridum [Inn-Latin]
Pharmacology
Finasteride is indicated for the treatment of male pattern hair loss (androgenetic alopecia) in men only. Finasteride is a competitive and specific inhibitor of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into DHT. Two distinct isozymes are found in mice, rats, monkeys, and humans: Type I and II. Each of these isozymes is differentially expressed in tissues and developmental stages. In humans, Type I 5a-reductase is predominant in the sebaceous glands of most regions of skin, including scalp, and liver. Type I 5a-reductase is responsible for approximately one-third of circulating DHT. The Type II 5a-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT.
Finasteridum [Inn-Latin]
Absorption
No information avaliable
Finasteridum [Inn-Latin]
side effects and Toxicity
No information avaliable
Finasteridum [Inn-Latin]
Patient Information
No information avaliable
Finasteridum [Inn-Latin]
Organisms Affected
Humans and other mammals