Eplerenone
Eplerenone Brand names, Eplerenone Analogs
Eplerenone Brand Names Mixture
- No information avaliable
Eplerenone Chemical_Formula
C24H30O6
Eplerenone RX_link
http://www.rxlist.com/cgi/generic/inspra.htm
Eplerenone fda sheet
Eplerenone msds (material safety sheet)
Eplerenone Synthesis Reference
No information avaliable
Eplerenone Molecular Weight
414.491 g/mol
Eplerenone Melting Point
No information avaliable
Eplerenone H2O Solubility
Slightly soluble
Eplerenone State
Solid
Eplerenone LogP
2.445
Eplerenone Dosage Forms
Tablet (film-coated - 25, 50 mg)
Eplerenone Indication
For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.
Eplerenone Pharmacology
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
Eplerenone Absorption
The absolute bioavailability of eplerenone is unknown.
Eplerenone side effects and Toxicity
The most likely symptoms of human overdosage would be anticipated to be hypotension or hyperkalemia. However, no cases of human overdosage with eplerenone have been reported.
Eplerenone Patient Information
Eplerenone Organisms Affected
Humans and other mammals
