Epoxymexrenone en es it fr

Epoxymexrenone Brand names, Epoxymexrenone Analogs

Epoxymexrenone Brand Names Mixture

  • No information avaliable

Epoxymexrenone Chemical_Formula


Epoxymexrenone RX_link


Epoxymexrenone fda sheet

Epoxymexrenone FDA

Epoxymexrenone msds (material safety sheet)

Epoxymexrenone Synthesis Reference

No information avaliable

Epoxymexrenone Molecular Weight

414.491 g/mol

Epoxymexrenone Melting Point

No information avaliable

Epoxymexrenone H2O Solubility

Slightly soluble

Epoxymexrenone State


Epoxymexrenone LogP


Epoxymexrenone Dosage Forms

Tablet (film-coated - 25, 50 mg)

Epoxymexrenone Indication

For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.

Epoxymexrenone Pharmacology

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.

Epoxymexrenone Absorption

The absolute bioavailability of eplerenone is unknown.

Epoxymexrenone side effects and Toxicity

The most likely symptoms of human overdosage would be anticipated to be hypotension or hyperkalemia. However, no cases of human overdosage with eplerenone have been reported.

Epoxymexrenone Patient Information

Epoxymexrenone Organisms Affected

Humans and other mammals