Embeline
Embeline Brand names, Embeline Analogs
Embeline Brand Names Mixture
- No information avaliable
Embeline Chemical_Formula
C25H32ClFO5
Embeline RX_link
http://www.rxlist.com/cgi/generic/olux.htm
Embeline fda sheet
Embeline msds (material safety sheet)
Embeline Synthesis Reference
No information avaliable
Embeline Molecular Weight
466.97 g/mol
Embeline Melting Point
195.5-197 oC
Embeline H2O Solubility
3.86 mg/L
Embeline State
Solid
Embeline LogP
3.588
Embeline Dosage Forms
Foam (0.05%) and ointment (usp 0.05%, supplied in 15 g, 30 g, and 45 g tubes)
Embeline Indication
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Embeline Pharmacology
Like other topical corticosteroids, clobetasol has anti-inflammatory, antipruritic, and vasoconstrictive properties. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Embeline Absorption
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Embeline side effects and Toxicity
Oral LD50 in rat and mouse is >3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Embeline Patient Information
Embeline Organisms Affected
Humans and other mammals
