Dermovate
Dermovate Brand names, Dermovate Analogs
Dermovate Brand Names Mixture
- No information avaliable
Dermovate Chemical_Formula
C25H32ClFO5
Dermovate RX_link
http://www.rxlist.com/cgi/generic/olux.htm
Dermovate fda sheet
Dermovate msds (material safety sheet)
Dermovate Synthesis Reference
No information avaliable
Dermovate Molecular Weight
466.97 g/mol
Dermovate Melting Point
195.5-197 oC
Dermovate H2O Solubility
3.86 mg/L
Dermovate State
Solid
Dermovate LogP
3.588
Dermovate Dosage Forms
Foam (0.05%) and ointment (usp 0.05%, supplied in 15 g, 30 g, and 45 g tubes)
Dermovate Indication
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Dermovate Pharmacology
Like other topical corticosteroids, clobetasol has anti-inflammatory, antipruritic, and vasoconstrictive properties. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Dermovate Absorption
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Dermovate side effects and Toxicity
Oral LD50 in rat and mouse is >3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Dermovate Patient Information
Dermovate Organisms Affected
Humans and other mammals
