Efalizumab
Efalizumab Brand names, Efalizumab Analogs
Efalizumab Brand Names Mixture
- No information avaliable
Efalizumab Chemical_Formula
No information avaliable
Efalizumab RX_link
http://www.rxlist.com/cgi/generic3/raptiva.htm
Efalizumab fda sheet
Efalizumab msds (material safety sheet)
Efalizumab Synthesis Reference
sequence listed in Werther WA, Gonzalez TN, O'Connor SJ, McCabe S, Chan B, Hotaling T, Champe M, Fox JA, Jardieu PM, Berman PW, Presta LG. Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1. J Immunol. 1996 Dec 1;157(11):4986-95
Efalizumab Molecular Weight
No information avaliable
Efalizumab Melting Point
61 oC (FAB fragment), 71 oC (whole mAb)-Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
Efalizumab H2O Solubility
No information avaliable
Efalizumab State
Liquid
Efalizumab LogP
No information avaliable
Efalizumab Dosage Forms
Solution (Subcutaneous Injection)
Efalizumab Indication
For treatment of psoriasis
Efalizumab Pharmacology
Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
Efalizumab Absorption
No information avaliable
Efalizumab side effects and Toxicity
No information avaliable
Efalizumab Patient Information
BIOD00074.html
Efalizumab Organisms Affected
Humans and other mammals
