anti alphaL integrin
anti alphaL integrin Brand names, anti alphaL integrin Analogs
anti alphaL integrin Brand Names Mixture
- No information avaliable
anti alphaL integrin Chemical_Formula
No information avaliable
anti alphaL integrin RX_link
http://www.rxlist.com/cgi/generic3/raptiva.htm
anti alphaL integrin fda sheet
anti alphaL integrin msds (material safety sheet)
anti alphaL integrin Synthesis Reference
sequence listed in Werther WA, Gonzalez TN, O'Connor SJ, McCabe S, Chan B, Hotaling T, Champe M, Fox JA, Jardieu PM, Berman PW, Presta LG. Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1. J Immunol. 1996 Dec 1;157(11):4986-95
anti alphaL integrin Molecular Weight
No information avaliable
anti alphaL integrin Melting Point
61 oC (FAB fragment), 71 oC (whole mAb)-Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).
anti alphaL integrin H2O Solubility
No information avaliable
anti alphaL integrin State
Liquid
anti alphaL integrin LogP
No information avaliable
anti alphaL integrin Dosage Forms
Solution (Subcutaneous Injection)
anti alphaL integrin Indication
For treatment of psoriasis
anti alphaL integrin Pharmacology
Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
anti alphaL integrin Absorption
No information avaliable
anti alphaL integrin side effects and Toxicity
No information avaliable
anti alphaL integrin Patient Information
BIOD00074.html
anti alphaL integrin Organisms Affected
Humans and other mammals
