Dornase alfa
Dornase alfa Brand names, Dornase alfa Analogs
Dornase alfa Brand Names Mixture
- No information avaliable
Dornase alfa Chemical_Formula
C1321H1999N339O396S9
Dornase alfa RX_link
http://www.rxlist.com/cgi/generic3/pulmozyme.htm
Dornase alfa fda sheet
Dornase alfa msds (material safety sheet)
Dornase alfa Synthesis Reference
No information avaliable
Dornase alfa Molecular Weight
29253.9
Dornase alfa Melting Point
67 oC (Chan, H.K. et al., Pharm Res. 13:756-761 (1996))
Dornase alfa H2O Solubility
No information avaliable
Dornase alfa State
Liquid
Dornase alfa LogP
-0.083
Dornase alfa Dosage Forms
Solution
Dornase alfa Indication
For treatment of cystic fibrosis
Dornase alfa Pharmacology
Cystic fibrosis (CF) is a disease characterized by the retention of viscous purulent secretions in the airways. These thick secretions contribute both to reduced pulmonary function and to frequent pulmonary infection. Purulent pulmonary secretions contain very high concentrations of extracellular DNA released by degenerating leukocytes that accumulate in response to these infections. Pulmozyme hydrolyzes the DNA in sputum of CF patients and reduces sputum viscoelasticity.
Dornase alfa Absorption
No information avaliable
Dornase alfa side effects and Toxicity
No information avaliable
Dornase alfa Patient Information
BIOD00001.html
Dornase alfa Organisms Affected
Humans and other mammals
