Dofetilide
Dofetilide Brand names, Dofetilide Analogs
Dofetilide Brand Names Mixture
- No information avaliable
Dofetilide Chemical_Formula
C19H27N3O5S2
Dofetilide RX_link
http://www.rxlist.com/cgi/generic2/dofetilide.htm
Dofetilide fda sheet
Dofetilide msds (material safety sheet)
Dofetilide Synthesis Reference
No information avaliable
Dofetilide Molecular Weight
441.567 g/mol
Dofetilide Melting Point
No information avaliable
Dofetilide H2O Solubility
No information avaliable
Dofetilide State
Solid
Dofetilide LogP
4.574
Dofetilide Dosage Forms
Capsule
Dofetilide Indication
For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
Dofetilide Pharmacology
Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm. Dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. At concentrations covering several orders of magnitude, Dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, Dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.
Dofetilide Absorption
>90%
Dofetilide side effects and Toxicity
No information avaliable
Dofetilide Patient Information
No information avaliable
Dofetilide Organisms Affected
Humans and other mammals
