PharmacyCodes



Dofetilida [Inn-Spanish] en es it fr

Dofetilida [Inn-Spanish] Brand names, Dofetilida [Inn-Spanish] Analogs

Dofetilida [Inn-Spanish] Brand Names Mixture

  • No information avaliable

Dofetilida [Inn-Spanish] Chemical_Formula

C19H27N3O5S2

Dofetilida [Inn-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/dofetilide.htm

Dofetilida [Inn-Spanish] fda sheet

Dofetilida_[Inn-Spanish] FDA

Dofetilida [Inn-Spanish] msds (material safety sheet)

Dofetilida [Inn-Spanish] Synthesis Reference

No information avaliable

Dofetilida [Inn-Spanish] Molecular Weight

441.567 g/mol

Dofetilida [Inn-Spanish] Melting Point

No information avaliable

Dofetilida [Inn-Spanish] H2O Solubility

No information avaliable

Dofetilida [Inn-Spanish] State

Solid

Dofetilida [Inn-Spanish] LogP

4.574

Dofetilida [Inn-Spanish] Dosage Forms

Capsule

Dofetilida [Inn-Spanish] Indication

For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm

Dofetilida [Inn-Spanish] Pharmacology

Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm. Dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. At concentrations covering several orders of magnitude, Dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, Dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.

Dofetilida [Inn-Spanish] Absorption

>90%

Dofetilida [Inn-Spanish] side effects and Toxicity

No information avaliable

Dofetilida [Inn-Spanish] Patient Information

No information avaliable

Dofetilida [Inn-Spanish] Organisms Affected

Humans and other mammals