PharmacyCodes



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Diphone Brand names, Diphone Analogs

Diphone Brand Names Mixture

  • No information avaliable

Diphone Chemical_Formula

C12H12N2O2S

Diphone RX_link

http://www.rxlist.com/cgi/generic3/dapsone.htm

Diphone fda sheet

Diphone msds (material safety sheet)

Diphone MSDS

Diphone Synthesis Reference

No information avaliable

Diphone Molecular Weight

248.302 g/mol

Diphone Melting Point

175.5 oC

Diphone H2O Solubility

380 mg/L

Diphone State

Solid

Diphone LogP

1.304

Diphone Dosage Forms

Tablet

Diphone Indication

For the treatment and management of leprosy and dermatitis herpetiformis

Diphone Pharmacology

Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic carinii pneumonia in AIDS patients. Dapsone is absorbed rapidly and nearly completely from the gastrointestinal tract. Dapsone is distributed throughout total body water and is present in all tissues. However, it tends to be retained in skin and muscle and especially in the liver and kidney: traces of the drug are present in these organs up to 3 weeks after therapy cessation.

Diphone Absorption

No information avaliable

Diphone side effects and Toxicity

No information avaliable

Diphone Patient Information

1. Patients should use ACZONE® Gel, 5%, as directed by the physician. ACZONE® Gel, 5%, is for external topical use only. ACZONE® Gel, 5%, is not for oral, ophthalmic or intravaginal use.

2. Patients should not use this medication for any disorder other than that for which it was prescribed.

3. Patients should tell their physician if they have any history of anemia or an enzyme deficiency (such as G6PD deficiency).

4. Patients should be informed as to the need for laboratory evaluation prior to starting ACZONE® Gel, 5%.

5. Patients should report any signs of adverse reactions to their physician.

6. Protect ACZONE® Gel, 5%, from freezing and light. Return to the original carton after application to protect from light.

PATIENT INSERT

ACZONE® (dapsone) Gel 5%

Read this important information before you start using ACZONE® (AK-zon) Gel and each time you refill your prescription. There may be new information that you need to know. This summary is not meant to take the place of your doctorís advice. If you have any questions or want more information about ACZONE® Gel, ask your doctor or pharmacist.

What is ACZONE® Gel?

ACZONE® Gel is a prescription skin use (topical) medicine used to help treat acne in people 12 years and older.

ACZONE® Gel has not been studied in children under 12 years of age.

Who should not use ACZONE® Gel?

Do not use ACZONE® Gel if you are allergic any of the ingredients in ACZONE® Gel. Ask your doctor or pharmacist for a list of these ingredients. The active ingredient is dapsone. See the end of this leaflet for a complete list of ingredients in ACZONE® Gel.

What should I tell my doctor before using ACZONE® Gel?

Tell your doctor about all of your medical conditions, including if you:

· are pregnant or planning to become pregnant. It is not known if ACZONE Gel may harm your unborn baby.

· are breastfeeding. ACZONE®Gel passes into your milk and may harm your baby. You should choose either to use ACZONE® Gel, or breastfeed, but not both. Talk to you doctor about the best way to feed your baby while using ACZONE® Gel.

· have a history of anemia or have been diagnosed with glucose-6-phosphate dehydrogenase deficiency

Tell your doctor about all the medicines you are taking including prescription and nonprescription medicines, vitamins and herbal supplements. Especially, tell your doctor if you are using any other medicines applied to the skin.

How do I use ACZONE® Gel?

· Use ACZONE® Gel exactly as prescribed by your doctor. ACZONE® Gel is usually used on your affected skin twice a day, once in the morning and once in the evening.

· Wash the areas of your skin where you will apply ACZONE® Gel. Gently pat your skin dry with a clean towel.

· Apply a thin layer of ACZONE® Gel to the areas of your skin that have acne. A pea- sized amount of ACZONE® Gel will usually be enough.

· Rub the medicine in gently and completely

· Make sure to put the cap back on the ACZONE® Gel tube. Close it tightly and put the tube back in its original box.

· Wash your hands after applying ACZONE® Gel.

· Keep ACZONE® Gel away from your mouth and eyes. Do not swallow ACZONE® Gel. If you swallow ACZONE® Gel, call your doctor or poison control center right away.

· If your acne does not get better after using ACZONE® for 12 weeks, talk to your doctor about other treatments for acne.

What are the possible side effects of ACZONE® Gel?

Like all medicines, ACZONE® Gel can cause some side effects. These side effects are usually mild. The most common side effects of ACZONE® Gel are dryness, redness, oiliness and peeling of the skin being treated.

Call your doctor if you have excessive tiredness or any side effects that do not go away or bother you. This is not a complete list of all the side effects. If you have any questions, ask your doctor or pharmacist.

How should I store ACZONE® Gel?

Store ACZONE® Gel at room temperature 68 to 76 ºF. Do not freeze ACZONE® Gel. Protect ACZONE® Gel tube from light. Store in original box after using it.

Keep ACZONE® Gel out of the reach of children less than 12 years of age.

Where can I find more information about ACZONE® Gel?

If you have any questions or want more information about ACZONE® Gel, ask your doctor or pharmacist. Your doctor or pharmacist can also give you a copy of the ACZONE® Gel Package Insert written for health professionals. Ask them to explain anything you do not understand.

You may call 1-800-727-7003 to obtain more information about ACZONE® Gel.

Diphone Organisms Affected

Mycobacteria