Daypro Alta
Brand names,
Daypro Alta
Analogs
Daypro Alta
Brand Names Mixture
Daypro Alta
Chemical_Formula
C18H15NO3
Daypro Alta
RX_link
http://www.rxlist.com/cgi/generic/oxaproz.htm
Daypro Alta
fda sheet
Daypro Alta
msds (material safety sheet)
Daypro Alta
Synthesis Reference
No information avaliable
Daypro Alta
Molecular Weight
293.317 g/mol
Daypro Alta
Melting Point
158 - 159 oC
Daypro Alta
H2O Solubility
Insoluble
Daypro Alta
State
Solid
Daypro Alta
LogP
4.8
Daypro Alta
Dosage Forms
Tablet
Daypro Alta
Indication
Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
Daypro Alta
Pharmacology
Oxaprozin is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Daypro Alta
Absorption
Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged. Antacids do not significantly affect the extent and rate of oxaprozin absorption.
Daypro Alta
side effects and Toxicity
Oral, mouse: LD50 = 1210 mg/kg; Oral, rabbit: LD50 = 172 mg/kg; Oral, rat: LD50 = 4470 mg/kg
Daypro Alta
Patient Information
Daypro, like other drugs of its class, can cause discomfort and, rarely, more serious side effects, such as
gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. Although serious
gastrointestinal tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the
signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative sign
or symptoms. Patients should be apprised of the importance of this follow-up.
Patients should report to their physicians the signs or symptoms of gastrointestinal ulceration or bleeding, skin
rash, weight gain, or edema.
Patients should be informed of the warning signs and symptoms of hepatotoxicity (e.g., nausea, fatigue, lethargy,
pruritus, jaundice, right upper quadrant tenderness, and “flu-like” symptoms). If these occur, patients
should be instructed to stop therapy and seek immediate medical therapy.
Patients should also be instructed to seek immediate emergency help in the case of an anaphylactoid reaction.
In late pregnancy, as with other NSAIDs, Daypro should be avoided because it will cause premature closure of the
ductus arteriosus.
Daypro Alta
Organisms Affected
Humans and other mammals