D-Brompheniramine
Brand names,
D-Brompheniramine
Analogs
D-Brompheniramine
Brand Names Mixture
- Drixoral Cold & Sinus (Dexbrompheniramine Maleate + Pseudoephedrine Sulfate)
- Drixoral Day/Night - Srt/Tabs (Dexbrompheniramine Maleate + Pseudoephedrine Sulfate)
- Drixoral Syrup (Dexbrompheniramine Maleate + Pseudoephedrine Sulfate)
- Drixtab Tab (Dexbrompheniramine Maleate + Pseudoephedrine Sulfate)
D-Brompheniramine
Chemical_Formula
C16H19BrN2
D-Brompheniramine
RX_link
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Dexbrompheniramine
D-Brompheniramine
fda sheet
D-Brompheniramine
msds (material safety sheet)
D-Brompheniramine
Synthesis Reference
No information avaliable
D-Brompheniramine
Molecular Weight
319.24 g/mol
D-Brompheniramine
Melting Point
No information avaliable
D-Brompheniramine
H2O Solubility
No information avaliable
D-Brompheniramine
State
Solid
D-Brompheniramine
LogP
3.74
D-Brompheniramine
Dosage Forms
Tablet
D-Brompheniramine
Indication
For treatment and relief of symptoms of allergies, hay fever, and colds
D-Brompheniramine
Pharmacology
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
D-Brompheniramine
Absorption
Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
D-Brompheniramine
side effects and Toxicity
Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
D-Brompheniramine
Patient Information
D-Brompheniramine
Organisms Affected
Humans and other mammals