Corgard

• Sympatholytics
• Antihypertensive Agents
• Anti-Arrhythmia Agents
• Adrenergic beta-Antagonists
• ATC:C07AA12

• Anabet
• Corgard
• Corzide
• Solgol

• Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
• Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)

C₁₇H₂₇NO₄

http://www.rxlist.com/cgi/generic3/nadolol.htm

F. P. Hauck et al., U.S. Pat. 3,935,267 (1976)

309.401 g/mol

124-136 ^oC

8330 mg/L

Solid

1.398

Tablets (20 mg, 40 mg, 80 mg, 120 mg, and 160 mg)

Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life, and is structurally similar to propranolol. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. Nadolol has no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, nadolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.

Absorption of nadolol after oral dosing is variable, averaging about 30 percent.

Oral, mouse: LD₅₀ = 4500mg/kg. Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.

Patients, especially those with evidence of coronary artery insufficiency, should be warned against interruption or discontinuation of nadolol therapy without the physician's advice. Although cardiac failure rarely occurs in properly selected patients, patients being treated with beta-adrenergic blocking agents should be advised to consult the physician at the first sign or symptom of impending failure. The patient should also be advised of a proper course in the event of an inadvertently missed dose.

Humans and other mammals