Colestid
Colestid Brand names, Colestid Analogs
Colestid Brand Names Mixture
- No information avaliable
Colestid Chemical_Formula
C25H48N6O8
Colestid RX_link
No information avaliable
Colestid fda sheet
Colestid msds (material safety sheet)
Colestid Synthesis Reference
No information avaliable
Colestid Molecular Weight
560.684 g/mol
Colestid Melting Point
138-140oC
Colestid H2O Solubility
1.2 mg/mL (at 20°C, 1.2%)
Colestid State
Solid
Colestid LogP
-0.478
Colestid Dosage Forms
Powder (vials of 500 mg or 2 g sterile powder for preparing injections or for oral use)
Colestid Indication
Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
Colestid Pharmacology
Deferoxamine, otherwise known as desferrioxamine or desferal, is a chelating agent used to remove excess iron or aluminum from the body. It acts by binding free iron or aluminum in the bloodstream and enhancing its elimination in the urine. By removing excess iron or aluminum, the agent reduces the damage done to various organs and tissues, such as the liver.
Colestid Absorption
Deferoxamine is rapidly absorbed after intramuscular or subcutaneous administration, but only poorly absorbed from the gastrointestinal tract in the presence of intact mucosa.
Colestid side effects and Toxicity
Intravenous LD50 in mouse, rat, and rabbit is 340 mg/kg, 520 mg/kg, and 600 mg/kg, respectively. Subcutaneous LD50 in mouse and rat is 1600 mg/kg and >1000 mg/kg, respectively. Oral LD50 in mouse and rat is >3000 mg/kg and >1000 mg/kg, respectively. Nephrotoxicity, ototoxicity and retinal toxicity have been reported following long-term administration for chronic iron overload.
Colestid Patient Information
Colestid Organisms Affected
Humans and other mammals
