UNITED STATES PHARMACOPEIAL CONVENTION INC -- DEFEROXAMINE MESYLATE -- 6505-00F036925
===================== Product Identification =====================
Product ID:DEFEROXAMINE MESYLATE
MSDS Date:04/13/1989
FSC:6505
NIIN:00F036925
MSDS Number: BVSRF
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:WILLIAM M HELLER
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128
============= Composition/Information on Ingredients =============
Ingred Name:DEFEROXAMINE MESYLATE *94-3*
CAS:138-14-7
RTECS #:UG5310000
Fraction by Wt: 100%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): 17300 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:TACHYCARDIA. POSSIBLE ALLERGIC
REACTION TO DUST IF INHALED/INGESTED/CONTACT W/SKIN.
EYE/SKIN/RESPIRATORY TRACT IRRITATION. POSSIBLE HYPERSENSITIZATION.
IRRITATING TO MUCOUS MEMBRANES & RESPIRATORY TRA CT. DEFEROXAMINE
IS NOT RECOMMENDED FORWOMEN OF CHILD-BEARING POTENTIAL/DURING EARLY
PREGNANCY. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:LOCALIZED IRRITATION, SWELLING, FLUSHING OF
SKIN, HYPOTENSION, BLURRING OF VISION, PAINFUL URINATION, RAPID
HEART RATE, ABDOMINAL DISCOMFORT, DIARRHEA, FEVER, ITCHING, SKIN
RASH, LEG CRAMPS.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL, RENAL
INSUFFICIENCY
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
EYES/SKIN: FLUSH W/COPIOUS AMOUNTS OF WATER. INGESTION: FLUSH MOUT
OUT W/WATER. OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
FOR SURROUNDING FIRE/MATERIALS.
Fire Fighting Procedures:EVACUATE AREA. WEAR SELF CONTAINED BREATHING
APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS
W/ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN
CONTACT W/DRY MATERIAL TO DISSIPATE STATIC.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
SITE.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN TIGHT CONTAINER. SHOULD BE
HANDLED/STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT
INTEGRITY. USE W/ADEQUATE VENTILATION.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
DUST/MIST/FUMES/VAPORS. USE W/ADEAUATE DUST CONROL. DON'T PERMIT
EATING/DRINKING/SMOKING NEAR MATERIAL.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR NIOSH APPROVED RESPIRATOR.
Ventilation:ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
INDIVIDUALS WORKING W/CHEMICALS SHOULD CONSIDER ALL CHEMICALS TO BE
POTENTIALLY HAZARDOUS EVEN IF THEIR INDIVIDUAL HAZARDS MAY BE
UNCHARACTERIZED/UNKNOWN. HEALTH HAZARDS CONT'D: IN CASES OF
MODERATE-S EVERE ACUTE IRON INTOXICATION, DEFEROXAMINE SHOULD BE
USED SINCE IRON IS ALSO TOXIC TO THE FETUS.
================== Physical/Chemical Properties ==================
Solubility in Water:COMPLETE
Appearance and Odor:WHITE TO OFF-WHITE CRYSTALLINE POWDER W/NO ODOR
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS
Hazardous Decomposition Products:TOXIC FUMES, NITROGEN OXIDES
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.