Colestid

UNITED STATES PHARMACOPEIAL CONVENTION INC -- DEFEROXAMINE MESYLATE -- 6505-00F036925
=====================  Product Identification  =====================

Product ID:DEFEROXAMINE MESYLATE
MSDS Date:04/13/1989
FSC:6505
NIIN:00F036925
MSDS Number: BVSRF
=== Responsible Party ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:WILLIAM M HELLER
CAGE:14128
=== Contractor Identification ===
Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Ingred Name:DEFEROXAMINE MESYLATE      *94-3*
CAS:138-14-7
RTECS #:UG5310000
Fraction by Wt: 100%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50 (RAT): 17300 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:TACHYCARDIA. POSSIBLE ALLERGIC
    REACTION TO DUST IF INHALED/INGESTED/CONTACT W/SKIN.
    EYE/SKIN/RESPIRATORY TRACT IRRITATION. POSSIBLE HYPERSENSITIZATION.
    IRRITATING TO MUCOUS MEMBRANES & RESPIRATORY TRA CT. DEFEROXAMINE
    IS NOT RECOMMENDED FORWOMEN OF CHILD-BEARING POTENTIAL/DURING EARLY
    PREGNANCY. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:LOCALIZED IRRITATION, SWELLING, FLUSHING OF
    SKIN, HYPOTENSION, BLURRING OF VISION, PAINFUL URINATION, RAPID
    HEART RATE, ABDOMINAL DISCOMFORT, DIARRHEA, FEVER, ITCHING, SKIN
    RASH, LEG CRAMPS.
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL, RENAL
    INSUFFICIENCY

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
    EYES/SKIN: FLUSH W/COPIOUS AMOUNTS OF WATER. INGESTION: FLUSH MOUT
    OUT W/WATER. OBTAIN MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE/MATERIALS.
Fire Fighting Procedures:EVACUATE AREA. WEAR SELF CONTAINED BREATHING
    APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS
    W/ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN
    CONTACT W/DRY MATERIAL TO DISSIPATE STATIC.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
    COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
    APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
    SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER. SHOULD BE
    HANDLED/STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT
    INTEGRITY. USE W/ADEQUATE VENTILATION.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
    DUST/MIST/FUMES/VAPORS. USE W/ADEAUATE DUST CONROL. DON'T PERMIT
    EATING/DRINKING/SMOKING NEAR MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR NIOSH APPROVED RESPIRATOR.
Ventilation:ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
INDIVIDUALS WORKING W/CHEMICALS SHOULD CONSIDER ALL CHEMICALS TO BE
    POTENTIALLY HAZARDOUS EVEN IF THEIR INDIVIDUAL HAZARDS MAY BE
    UNCHARACTERIZED/UNKNOWN. HEALTH HAZARDS CONT'D: IN CASES OF
    MODERATE-S EVERE ACUTE IRON INTOXICATION, DEFEROXAMINE SHOULD BE
    USED SINCE IRON IS ALSO TOXIC TO THE FETUS.

==================  Physical/Chemical Properties  ==================

Solubility in Water:COMPLETE
Appearance and Odor:WHITE TO OFF-WHITE CRYSTALLINE POWDER W/NO ODOR

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS
Hazardous Decomposition Products:TOXIC FUMES, NITROGEN OXIDES

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.