Colesevelam
Colesevelam Brand names, Colesevelam Analogs
Colesevelam Brand Names Mixture
- No information avaliable
Colesevelam Chemical_Formula
No information avaliable
Colesevelam RX_link
http://www.rxlist.com/cgi/generic2/colesevelam.htm
Colesevelam fda sheet
Colesevelam msds (material safety sheet)
Colesevelam Synthesis Reference
No information avaliable
Colesevelam Molecular Weight
618.248 g/mol
Colesevelam Melting Point
No information avaliable
Colesevelam H2O Solubility
Insoluble
Colesevelam State
Solid
Colesevelam LogP
No information avaliable
Colesevelam Dosage Forms
Tablets (off-white, film-coated, solid tablets containing 625 mg colesevelam)
Colesevelam Indication
For use, alone or in combination with an HMG-CoA reductase inhibitor, as adjunctive therapy to diet and exercise for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia (Fredrickson Type IIa).
Colesevelam Pharmacology
Colesevelam is a high capacity bile-acid binding molecule. Colesevelam binds to bile acids in the intestine which reduces the amount of bile acids that are returned to the liver via enterohepatic circulation. Clinical studies have demonstrated that elevated levels of total cholesterol (total-C), LDL-C, and apolipoprotein B (Apo B, a protein associated with LDL-C) are associated with an increased risk of atherosclerosis in humans. Similarly, decreased levels of high-density lipoprotein cholesterol (HDL-C) are associated with the development of atherosclerosis. Epidemiological investigations have established that cardiovascular morbidity and mortality vary directly with the levels of total-C and LDL-C, and inversely with the level of HDL-C. The combination of colesevelam and an HMG-CoA reductase inhibitor is effective in further lowering serum total-C and LDL-C levels beyond that achieved by either agent alone.
Colesevelam Absorption
Not hydrolyzed by digestive enzymes and is not absorbed.
Colesevelam side effects and Toxicity
Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colesevelam is not absorbed, the risk of systemic toxicity is low. Doses in excess of 4.5 g per day have not been tested.
Colesevelam Patient Information
Colesevelam Organisms Affected
Humans and other mammals
