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Carphenazin Brand names, Carphenazin Analogs

Carphenazin Brand Names Mixture

  • No information avaliable

Carphenazin Chemical_Formula

No information avaliable

Carphenazin RX_link

Carphenazin fda sheet

Carphenazin FDA

Carphenazin msds (material safety sheet)

Carphenazin Synthesis Reference

No information avaliable

Carphenazin Molecular Weight

618.248 g/mol

Carphenazin Melting Point

No information avaliable

Carphenazin H2O Solubility


Carphenazin State


Carphenazin LogP

No information avaliable

Carphenazin Dosage Forms

Tablets (off-white, film-coated, solid tablets containing 625 mg colesevelam)

Carphenazin Indication

For use, alone or in combination with an HMG-CoA reductase inhibitor, as adjunctive therapy to diet and exercise for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia (Fredrickson Type IIa).

Carphenazin Pharmacology

Colesevelam is a high capacity bile-acid binding molecule. Colesevelam binds to bile acids in the intestine which reduces the amount of bile acids that are returned to the liver via enterohepatic circulation. Clinical studies have demonstrated that elevated levels of total cholesterol (total-C), LDL-C, and apolipoprotein B (Apo B, a protein associated with LDL-C) are associated with an increased risk of atherosclerosis in humans. Similarly, decreased levels of high-density lipoprotein cholesterol (HDL-C) are associated with the development of atherosclerosis. Epidemiological investigations have established that cardiovascular morbidity and mortality vary directly with the levels of total-C and LDL-C, and inversely with the level of HDL-C. The combination of colesevelam and an HMG-CoA reductase inhibitor is effective in further lowering serum total-C and LDL-C levels beyond that achieved by either agent alone.

Carphenazin Absorption

Not hydrolyzed by digestive enzymes and is not absorbed.

Carphenazin side effects and Toxicity

Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colesevelam is not absorbed, the risk of systemic toxicity is low. Doses in excess of 4.5 g per day have not been tested.

Carphenazin Patient Information

Carphenazin Organisms Affected

Humans and other mammals