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Cibacen Brand names, Cibacen Analogs

Cibacen Brand Names Mixture

  • Lotensin HCT (Benazepril Hydrochloride + Hydrochlorothiazide)
  • Lotrel (Benazepril Hydrochloride + Amlodipine Besylate)

Cibacen Chemical_Formula


Cibacen RX_link

Cibacen fda sheet

Cibacen FDA

Cibacen msds (material safety sheet)

Cibacen MSDS

Cibacen Synthesis Reference


Cibacen Molecular Weight

424.49 g/mol

Cibacen Melting Point

148-149 oC

Cibacen H2O Solubility

2.229 mg/L

Cibacen State


Cibacen LogP


Cibacen Dosage Forms

Tablet (5 mg, 10 mg, 20 mg, 40 mg)

Cibacen Indication

For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

Cibacen Pharmacology

Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by estarases to its active Benazeprilat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.

Cibacen Absorption

Peak in plasma within 0.5-1.0 hours. The extent of absorption is at least 37% as determined by urinary recovery and is not significantly influenced by the presence of food in the GI tract.

Cibacen side effects and Toxicity

Symptoms of overdose include swelling of face, mouth, hands, or feet, trouble in swallowing or breathing (sudden), hoarseness, fever and chills.

Cibacen Patient Information


Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to ACE inhibitors, and they should also be told that these consequences do not appear to have resulted from intrauterine ACE inhibitor exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.


Angioedema, including laryngeal edema, can occur at any time with treatment with ACE inhibitors. Patients should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, eyes, lips, or tongue, or difficulty in breathing) and to take no more drug until they have consulted with the prescribing physician.

Symptomatic Hypotension

Patients should be cautioned that lightheadedness can occur, especially during the first days of therapy, and it should be reported to the prescribing physician. Patients should be told that if syncope occurs, Lotensin should be discontinued until the prescribing physician has been consulted.

All patients should be cautioned that inadequate fluid intake or excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope.


Patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician.


Patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia.

Cibacen Organisms Affected

Humans and other mammals