Chinine
Chinine Brand names, Chinine Analogs
Chinine Brand Names Mixture
- Holis 12 Pr (Aloe + Citrullus Colocynthis + Gamboge + Podophyllum + Quinine + White Hellebore Root)
- Holis 21 (Castanea Vesca + Citrullus Colocynthis + Ipecac + Nitric Acid + Quinine + Silver Nitrate)
- Holis 22 (Carbon Disulfide + Chenopodium Ambrosioides + Quinine Sulfate + Tobacco)
- Holis 73 (Asafetida + Charcoal Activated + Gratiola Officinalis + Lycopodium Clavatum + Magnesium Carbonate + Potassium Carbonate + Quinine + Silver Nitrate)
- Holis 78 (Aconitinum + Cedron + Citrullus Colocynthis + Hypericum Perforatum + Plantago Major + Quinine + Quinine Sulfate)
- Holis 82 (Acetic Acid + Asafetida + Charcoal Activated + Magnesium Carbonate + Potassium Carbonate + Quinine + Radish + Silver Nitrate)
- Salzmann Product M-1 Malena (Potassium Nitrate + Potassium Phosphate Dibasic + Quinine Sulfate + Sodium Chloride + Sodium Sulfate + Sodium Sulfite)
- Thc Complex #57 (Arnica Montana + Barium Carbonate + Belladonna + Carbon Disulfide + Cinchona Officinalis + Cocculus Indicus + Conium Maculatum + Ferrum Phosphoricum + Gelsemium Sempervirens + German Chamomile + Hahnemann's Causticum + Lycopodium Clavatum + Oyster Shells + Phosphorus + Pomegranate Bark + Quinine Sulfate + Salicylic Acid + Sanguinaria Canadensis + Sulfur)
- Triogene for (Calcium Glycerophosphate + Gentiana Lutea + Iron + Kola + Quinine)
Chinine Chemical_Formula
C20H24N2O2
Chinine RX_link
http://www.rxlist.com/cgi/generic3/quinine.htm
Chinine fda sheet
Chinine msds (material safety sheet)
Chinine Synthesis Reference
Woodward, Doering, J. Am. Chem. Soc. 66, 849 (1944); 67, 860 (1945)
Chinine Molecular Weight
324.417 g/mol
Chinine Melting Point
57 oC
Chinine H2O Solubility
500 mg/L
Chinine State
Solid
Chinine LogP
2.534
Chinine Dosage Forms
Capsule; Drops; Injection; Tablet
Chinine Indication
For the treatment of malaria and leg cramps
Chinine Pharmacology
Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine.
Chinine Absorption
76 - 88%
Chinine side effects and Toxicity
No information avaliable
Chinine Patient Information
Chinine Organisms Affected
Humans and other mammals
