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Cetuximab Brand names, Cetuximab Analogs

Cetuximab Brand Names Mixture

  • Actinac Pwr (Allantoin + Butoxyethyl Nicotinate + Chloramphenicol + Hydrocortisone Acetate + Sulfur)
  • Actinac Pws (Allantoin + Butoxyethyl Nicotinate + Chloramphenicol + Hydrocortisone Acetate + Sulfur)
  • Chlorasone (Chloramphenicol + Prednisolone Acetate)
  • Elase Chloromycetin Ont (Chloramphenicol + Deoxyribonuclease Pancreatic + Fibrinolysin)
  • Liquichlor (Chloramphenicol + Prednisolone + Squalane + Tetracaine)
  • Ophthocort Ont (Chloramphenicol + Hydrocortisone Acetate + Polymyxin B)
  • Sopamycetin/Hc Ointment (Chloramphenicol + Hydrocortisone Acetate)
  • Sopamycetin/Hc Ont (Chloramphenicol + Hydrocortisone Acetate)
  • Sopamycetin/Hc Susp (Chloramphenicol + Hydrocortisone Acetate)
  • Zoomycetine Spray (Chloramphenicol + Isopropyl Alcohol + Methyl Violet)

Cetuximab Chemical_Formula

C6484H10042N1732O2023S36

Cetuximab RX_link

http://www.rxlist.com/cgi/generic3/erbitux.htm

Cetuximab fda sheet

Cetuximab FDA

Cetuximab msds (material safety sheet)

Cetuximab Synthesis Reference

sequence listed in Goldstein N. I., Prewett M., Zuklys K., Rockwell P., Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res., 1: 1311-1318, 1995.) patent 6,217,866

Cetuximab Molecular Weight

145781.6

Cetuximab Melting Point

61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).

Cetuximab H2O Solubility

No information avaliable

Cetuximab State

Liquid

Cetuximab LogP

-0.413

Cetuximab Dosage Forms

Solution (IV Infusion)

Cetuximab Indication

For treatment of metastatic colorectal cancer

Cetuximab Pharmacology

Used in the treatment of colorectal cancer, Erbitux binds specifically to the epidermal growth factor receptor (EGFr, HER1, c-ErbB-1) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Erbitux competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor??“alpha. Binding of Erbitux to the EGFr blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, decreased matrix metalloproteinase secretion and reduced vascular endothelial growth factor production.

Cetuximab Absorption

No information avaliable

Cetuximab side effects and Toxicity

No information avaliable

Cetuximab Patient Information

No information avaliable

Cetuximab Organisms Affected

Humans and other mammals