Ceftriaxona [Inn-Spanish]
Brand names,
Ceftriaxona [Inn-Spanish]
Analogs
Ceftriaxona [Inn-Spanish]
Brand Names Mixture
Ceftriaxona [Inn-Spanish]
Chemical_Formula
C18H18N8O7S3
Ceftriaxona [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic3/ceftriax.htm
Ceftriaxona [Inn-Spanish]
fda sheet
Ceftriaxona [Inn-Spanish]
msds (material safety sheet)
Ceftriaxona [Inn-Spanish]
Synthesis Reference
M. Montavon, R. Reiner, Brit. pat. Appl. 2,022,090; eidem, U.S. pat. 4,327,210 (1979, 1982 both to Hoffmann-La Roche)
Ceftriaxona [Inn-Spanish]
Molecular Weight
554.583 g/mol
Ceftriaxona [Inn-Spanish]
Melting Point
>155 oC
Ceftriaxona [Inn-Spanish]
H2O Solubility
No information avaliable
Ceftriaxona [Inn-Spanish]
State
Solid
Ceftriaxona [Inn-Spanish]
LogP
-1.341
Ceftriaxona [Inn-Spanish]
Dosage Forms
IM infusion;
Ceftriaxona [Inn-Spanish]
Indication
For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Ceftriaxona [Inn-Spanish]
Pharmacology
Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ceftriaxone results from the inhibition of cell wall synthesis and is mediated through Ceftriaxone binding to penicillin binding proteins (PBPs). Ceftriaxone is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Ceftriaxona [Inn-Spanish]
Absorption
No information avaliable
Ceftriaxona [Inn-Spanish]
side effects and Toxicity
No information avaliable
Ceftriaxona [Inn-Spanish]
Patient Information
Patient Information:
Patients should be counseled that antibacterial drugs including Ceftriaxone should only be used to
treat bacterial infections. They do not treat viral infections (eg, common cold). When Ceftriaxone
is prescribed to treat a bacterial infection, patients should be told that although it is common
to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of
the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and
will not be treatable by Ceftriaxone or other antibacterial drugs in the future.
Ceftriaxona [Inn-Spanish]
Organisms Affected
Enteric bacteria and other eubacteria