Carboplatin (USAN)
Carboplatin (USAN) Brand names, Carboplatin (USAN) Analogs
Carboplatin (USAN) Brand Names Mixture
- No information avaliable
Carboplatin (USAN) Chemical_Formula
C6H12N2O4Pt2
Carboplatin (USAN) RX_link
http://www.rxlist.com/cgi/generic3/carboplat.htm
Carboplatin (USAN) fda sheet
Carboplatin (USAN) msds (material safety sheet)
Carboplatin (USAN) Synthesis Reference
No information avaliable
Carboplatin (USAN) Molecular Weight
371.249 g/mol
Carboplatin (USAN) Melting Point
No information avaliable
Carboplatin (USAN) H2O Solubility
No information avaliable
Carboplatin (USAN) State
Solid
Carboplatin (USAN) LogP
No information avaliable
Carboplatin (USAN) Dosage Forms
Solution
Carboplatin (USAN) Indication
For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide.
Carboplatin (USAN) Pharmacology
Carboplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Carboplatin (USAN) Absorption
No information avaliable
Carboplatin (USAN) side effects and Toxicity
Toxic by ingestion. May be create toxic effect through inhalation or skin contact. May cause reproductive defects. May act as a sensitizer.
Carboplatin (USAN) Patient Information
No information avaliable
Carboplatin (USAN) Organisms Affected
Humans and other mammals
