Balsalazide
Balsalazide Brand names, Balsalazide Analogs
Balsalazide Brand Names Mixture
- No information avaliable
Balsalazide Chemical_Formula
C17H15N3O6
Balsalazide RX_link
http://www.rxlist.com/cgi/generic2/balsalazide.htm
Balsalazide fda sheet
Balsalazide msds (material safety sheet)
Balsalazide Synthesis Reference
No information avaliable
Balsalazide Molecular Weight
357.318 g/mol
Balsalazide Melting Point
No information avaliable
Balsalazide H2O Solubility
Freely soluble as disodium salt
Balsalazide State
Solid
Balsalazide LogP
2.417
Balsalazide Dosage Forms
Capsule (750 mg)
Balsalazide Indication
For the treatment of mildly to moderately active ulcerative colitis.
Balsalazide Pharmacology
Balsalazide is a prodrug that is enzymatically cleaved in the colon to produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug indicated for the treatment of mildly to moderately active ulcerative colitis. Balsalazide disodium is delivered intact to the colon where it is cleaved by bacterial azoreduction to release equimolar quantities of mesalamine, which is the therapeutically active portion of the molecule, and 4-aminobenzoyl-(beta)-alanine.
Balsalazide Absorption
Low and variable, intact balsalazide is poorly absorbed systemically.
Balsalazide side effects and Toxicity
A single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.
Balsalazide Patient Information
No information avaliable
Balsalazide Organisms Affected
Humans and other mammals
