Colazal
Colazal Brand names, Colazal Analogs
Colazal Brand Names Mixture
- No information avaliable
Colazal Chemical_Formula
C17H15N3O6
Colazal RX_link
http://www.rxlist.com/cgi/generic2/balsalazide.htm
Colazal fda sheet
Colazal msds (material safety sheet)
Colazal Synthesis Reference
No information avaliable
Colazal Molecular Weight
357.318 g/mol
Colazal Melting Point
No information avaliable
Colazal H2O Solubility
Freely soluble as disodium salt
Colazal State
Solid
Colazal LogP
2.417
Colazal Dosage Forms
Capsule (750 mg)
Colazal Indication
For the treatment of mildly to moderately active ulcerative colitis.
Colazal Pharmacology
Balsalazide is a prodrug that is enzymatically cleaved in the colon to produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug indicated for the treatment of mildly to moderately active ulcerative colitis. Balsalazide disodium is delivered intact to the colon where it is cleaved by bacterial azoreduction to release equimolar quantities of mesalamine, which is the therapeutically active portion of the molecule, and 4-aminobenzoyl-(beta)-alanine.
Colazal Absorption
Low and variable, intact balsalazide is poorly absorbed systemically.
Colazal side effects and Toxicity
A single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.
Colazal Patient Information
No information avaliable
Colazal Organisms Affected
Humans and other mammals
