Carbadox
Carbadox Brand names, Carbadox Analogs
Carbadox Brand Names Mixture
- No information avaliable
Carbadox Chemical_Formula
C17H15N3O6
Carbadox RX_link
http://www.rxlist.com/cgi/generic2/balsalazide.htm
Carbadox fda sheet
Carbadox msds (material safety sheet)
Carbadox Synthesis Reference
No information avaliable
Carbadox Molecular Weight
357.318 g/mol
Carbadox Melting Point
No information avaliable
Carbadox H2O Solubility
Freely soluble as disodium salt
Carbadox State
Solid
Carbadox LogP
2.417
Carbadox Dosage Forms
Capsule (750 mg)
Carbadox Indication
For the treatment of mildly to moderately active ulcerative colitis.
Carbadox Pharmacology
Balsalazide is a prodrug that is enzymatically cleaved in the colon to produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug indicated for the treatment of mildly to moderately active ulcerative colitis. Balsalazide disodium is delivered intact to the colon where it is cleaved by bacterial azoreduction to release equimolar quantities of mesalamine, which is the therapeutically active portion of the molecule, and 4-aminobenzoyl-(beta)-alanine.
Carbadox Absorption
Low and variable, intact balsalazide is poorly absorbed systemically.
Carbadox side effects and Toxicity
A single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.
Carbadox Patient Information
No information avaliable
Carbadox Organisms Affected
Humans and other mammals
