Asparaginase
Brand names,
Asparaginase
Analogs
Asparaginase
Brand Names Mixture
Asparaginase
Chemical_Formula
C1377H2208N382O442S17
Asparaginase
RX_link
http://www.rxlist.com/cgi/generic3/asparaginase.htm
Asparaginase
fda sheet
Asparaginase
msds (material safety sheet)
Asparaginase
Synthesis Reference
No information avaliable
Asparaginase
Molecular Weight
31731.9
Asparaginase
Melting Point
No information avaliable
Asparaginase
H2O Solubility
No information avaliable
Asparaginase
State
Liquid
Asparaginase
LogP
0.059
Asparaginase
Dosage Forms
Powder for solution; Solution (IV or IM injection)
Asparaginase
Indication
For treatment of acute lympocytic leukemia and non-Hodgkins lymphoma
Asparaginase
Pharmacology
In a significant number of patients with acute leukemia, the malignant cells are dependent on an exogenous source of asparagine for survival. Normal cells, however, are able to synthesize asparagine and thus are affected less by the rapid depletion produced by treatment with the enzyme asparaginase. Elspar exploits a metabolic defect in asparagine synthesis of some malignant cells.
Asparaginase
Absorption
No information avaliable
Asparaginase
side effects and Toxicity
No information avaliable
Asparaginase
Patient Information
No information avaliable
Asparaginase
Organisms Affected
Humans and other mammals