Aminohippurate
Aminohippurate Brand names, Aminohippurate Analogs
Aminohippurate Brand Names Mixture
- No information avaliable
Aminohippurate Chemical_Formula
C9H10N2O3
Aminohippurate RX_link
http://www.rxlist.com/cgi/generic2/aminohippurate.htm
Aminohippurate fda sheet
Aminohippurate msds (material safety sheet)
Aminohippurate Synthesis Reference
No information avaliable
Aminohippurate Molecular Weight
194.187 g/mol
Aminohippurate Melting Point
199-200 oC
Aminohippurate H2O Solubility
Slightly soluble
Aminohippurate State
Solid
Aminohippurate LogP
-0.052
Aminohippurate Dosage Forms
Solution for injection (1g drug per 5mL solution)
Aminohippurate Indication
Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
Aminohippurate Pharmacology
Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. It is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of aminohippurate is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses, and its analytical determination is relatively simple and accurate. Aminohippurate is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (TmPAH). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete aminohippurate. Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate (GFR) must be known before calculations of secretory Tm measurements can be done.
Aminohippurate Absorption
No information avaliable
Aminohippurate side effects and Toxicity
No information avaliable
Aminohippurate Patient Information
Aminohippurate Organisms Affected
Humans and other mammals
