Aminohippuric acid
Aminohippuric acid Brand names, Aminohippuric acid Analogs
Aminohippuric acid Brand Names Mixture
- No information avaliable
Aminohippuric acid Chemical_Formula
C9H10N2O3
Aminohippuric acid RX_link
http://www.rxlist.com/cgi/generic2/aminohippurate.htm
Aminohippuric acid fda sheet
Aminohippuric acid msds (material safety sheet)
Aminohippuric acid Synthesis Reference
No information avaliable
Aminohippuric acid Molecular Weight
194.187 g/mol
Aminohippuric acid Melting Point
199-200 oC
Aminohippuric acid H2O Solubility
Slightly soluble
Aminohippuric acid State
Solid
Aminohippuric acid LogP
-0.052
Aminohippuric acid Dosage Forms
Solution for injection (1g drug per 5mL solution)
Aminohippuric acid Indication
Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
Aminohippuric acid Pharmacology
Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. It is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of aminohippurate is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses, and its analytical determination is relatively simple and accurate. Aminohippurate is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (TmPAH). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete aminohippurate. Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate (GFR) must be known before calculations of secretory Tm measurements can be done.
Aminohippuric acid Absorption
No information avaliable
Aminohippuric acid side effects and Toxicity
No information avaliable
Aminohippuric acid Patient Information
Aminohippuric acid Organisms Affected
Humans and other mammals
