Amgen)
Amgen) Brand names, Amgen) Analogs
Amgen) Brand Names Mixture
- No information avaliable
Amgen) Chemical_Formula
C860H1353N227O255S9
Amgen) RX_link
http://www.rxlist.com/cgi/generic2/infergen.htm
Amgen) fda sheet
Amgen) msds (material safety sheet)
Amgen) Synthesis Reference
No information avaliable
Amgen) Molecular Weight
19343
Amgen) Melting Point
61 oC (Beldarrain, A. et al., Biochemistry 38:7865-7873 (1999))Davis JM, Narachi MA, Levine HL, Alton NK, Arakawa T. Conformation and stability of two recombinant human interferon-alpha analogs.
Amgen) H2O Solubility
No information avaliable
Amgen) State
Liquid
Amgen) LogP
-0.336
Amgen) Dosage Forms
Solution
Amgen) Indication
For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma
Amgen) Pharmacology
Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.
Amgen) Absorption
No information avaliable
Amgen) side effects and Toxicity
No information avaliable
Amgen) Patient Information
BIOD00062.html
Amgen) Organisms Affected
No information avaliable
