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Amgen) Brand names, Amgen) Analogs

Amgen) Brand Names Mixture

  • No information avaliable

Amgen) Chemical_Formula

C860H1353N227O255S9

Amgen) RX_link

http://www.rxlist.com/cgi/generic2/infergen.htm

Amgen) fda sheet

Amgen) msds (material safety sheet)

Amgen) Synthesis Reference

No information avaliable

Amgen) Molecular Weight

19343

Amgen) Melting Point

61 oC (Beldarrain, A. et al., Biochemistry 38:7865-7873 (1999))Davis JM, Narachi MA, Levine HL, Alton NK, Arakawa T. Conformation and stability of two recombinant human interferon-alpha analogs.

Amgen) H2O Solubility

No information avaliable

Amgen) State

Liquid

Amgen) LogP

-0.336

Amgen) Dosage Forms

Solution

Amgen) Indication

For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma

Amgen) Pharmacology

Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.

Amgen) Absorption

No information avaliable

Amgen) side effects and Toxicity

No information avaliable

Amgen) Patient Information

BIOD00062.html

Amgen) Organisms Affected

No information avaliable