Abbokinase (Abbott Laboratories)
Brand names,
Abbokinase (Abbott Laboratories)
Analogs
Abbokinase (Abbott Laboratories)
Brand Names Mixture
Abbokinase (Abbott Laboratories)
Chemical_Formula
C1376H2145N383O406S18
Abbokinase (Abbott Laboratories)
RX_link
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE
Abbokinase (Abbott Laboratories)
fda sheet
Abbokinase (Abbott Laboratories)
msds (material safety sheet)
Abbokinase (Abbott Laboratories)
Synthesis Reference
PMID 2987867
Abbokinase (Abbott Laboratories)
Molecular Weight
31126.5
Abbokinase (Abbott Laboratories)
Melting Point
76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994).
Abbokinase (Abbott Laboratories)
H2O Solubility
No information avaliable
Abbokinase (Abbott Laboratories)
State
Liquid
Abbokinase (Abbott Laboratories)
LogP
-0.466
Abbokinase (Abbott Laboratories)
Dosage Forms
Powder for solution; Solution (IV infusion)
Abbokinase (Abbott Laboratories)
Indication
For the treatment of pulminary embolism, coronary artery thrombosis and IV catheter clearance
Abbokinase (Abbott Laboratories)
Pharmacology
Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
Abbokinase (Abbott Laboratories)
Absorption
No information avaliable
Abbokinase (Abbott Laboratories)
side effects and Toxicity
No information avaliable
Abbokinase (Abbott Laboratories)
Patient Information
http://www.drugs.com/PDR/Abbokinase.html
Abbokinase (Abbott Laboratories)
Organisms Affected
Humans and other mammals