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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C22H36N2O5S
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RX_link
http://www.rxlist.com/cgi/generic/tiro.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
440.598 g/mol
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Melting Point
No information avaliable
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H2O Solubility
Very slightly soluble
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State
Solid
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LogP
3.54
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Dosage Forms
Liquid; Solution
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Indication
For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
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Pharmacology
Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. When administered intravenously, tirofiban inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner. When given according to the recommended regimen, >90% inhibition is attained by the end of the 30-minute infusion. Tirofiban has been recently shown in patients with unstable angina to reduce ischemic events at 48 hours following infusion when compared to standard heparin therapy.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
Follow all instructions for proper mixing or dilution (if necessary) and
refer to the tirofiban dosing chart for the recommended IV dosing. If you have questions regarding the use of this
medication, consult your pharmacist. Give this medication by vein (IV) as an initial dose (bolus dose) followed by an
IV infusion as directed by your doctor. The dosage is based on your weight, medical condition, and response to
therapy. Before using, check this product visually for particles or discoloration. If either is present, do not use
the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.
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Organisms Affected
Humans and other mammals