Vinblastine
Vinblastine Brand names, Vinblastine Analogs
Vinblastine Brand Names Mixture
- No information avaliable
Vinblastine Chemical_Formula
C46H58N4O9
Vinblastine RX_link
http://www.rxlist.com/cgi/generic3/vinblastine.htm
Vinblastine fda sheet
Vinblastine msds (material safety sheet)
Vinblastine Synthesis Reference
No information avaliable
Vinblastine Molecular Weight
810.974 g/mol
Vinblastine Melting Point
267 oC
Vinblastine H2O Solubility
Negligible
Vinblastine State
Solid
Vinblastine LogP
5.587
Vinblastine Dosage Forms
Liquid; Powder for solution; Solution
Vinblastine Indication
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Vinblastine Pharmacology
Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vinblastine Absorption
No information avaliable
Vinblastine side effects and Toxicity
Oral, mouse: LD50 = 423 mg/kg; Oral, rat: LD50 = 305 mg/kg.
Vinblastine Patient Information
Vinblastine Organisms Affected
Humans and other mammals
