Vinblastin

• Antineoplastic Agents, Phytogenic
• ATC:L01CA01

• Indole Alkaloid
• Nincaluicolflastine
• Rozevin
• Velban
• Velbe
• Vinblastin
• Vinblastina [Dcit]
• Vinblastine Sulfate
• Vinblastinum [Inn-Latin]
• Vincaleucoblastin
• Vincaleucoblastine
• Vincaleukoblastine
• Vincoblastine

• No information avaliable

C₄₆H₅₈N₄O₉

http://www.rxlist.com/cgi/generic3/vinblastine.htm

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=29

Vinblastin MSDS

No information avaliable

810.974 g/mol

267 ^oC

Negligible

Solid

5.587

Liquid; Powder for solution; Solution

For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

No information avaliable

Oral, mouse: LD₅₀ = 423 mg/kg; Oral, rat: LD₅₀ = 305 mg/kg.

Humans and other mammals