Velbe
Velbe Brand names, Velbe Analogs
Velbe Brand Names Mixture
- No information avaliable
Velbe Chemical_Formula
C46H58N4O9
Velbe RX_link
http://www.rxlist.com/cgi/generic3/vinblastine.htm
Velbe fda sheet
Velbe msds (material safety sheet)
Velbe Synthesis Reference
No information avaliable
Velbe Molecular Weight
810.974 g/mol
Velbe Melting Point
267 oC
Velbe H2O Solubility
Negligible
Velbe State
Solid
Velbe LogP
5.587
Velbe Dosage Forms
Liquid; Powder for solution; Solution
Velbe Indication
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Velbe Pharmacology
Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Velbe Absorption
No information avaliable
Velbe side effects and Toxicity
Oral, mouse: LD50 = 423 mg/kg; Oral, rat: LD50 = 305 mg/kg.
Velbe Patient Information
Velbe Organisms Affected
Humans and other mammals
