Methylergometrin en es it fr

Methylergometrin Brand names, Methylergometrin Analogs

Methylergometrin Brand Names Mixture

  • No information avaliable

Methylergometrin Chemical_Formula


Methylergometrin RX_link

Methylergometrin fda sheet

Methylergometrin msds (material safety sheet)

Methylergometrin MSDS

Methylergometrin Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methylergometrin Molecular Weight

339.432 g/mol

Methylergometrin Melting Point

172 oC

Methylergometrin H2O Solubility

25 mg/mL

Methylergometrin State


Methylergometrin LogP


Methylergometrin Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methylergometrin Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methylergometrin Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methylergometrin Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methylergometrin side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergometrin Patient Information

Methylergometrin Organisms Affected

Humans and other mammals