Methylergometrine en es it fr

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Methylergometrine
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Methylergometrine Brand names, Methylergometrine Analogs

Methylergometrine Brand Names Mixture

  • No information avaliable

Methylergometrine Chemical_Formula

C20H25N3O2

Methylergometrine RX_link

http://www.rxlist.com/cgi/generic2/methylerg.htm

Methylergometrine fda sheet

Methylergometrine msds (material safety sheet)

Methylergometrine MSDS

Methylergometrine Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methylergometrine Molecular Weight

339.432 g/mol

Methylergometrine Melting Point

172 oC

Methylergometrine H2O Solubility

25 mg/mL

Methylergometrine State

Solid

Methylergometrine LogP

1.01

Methylergometrine Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methylergometrine Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methylergometrine Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methylergometrine Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methylergometrine side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergometrine Patient Information

Methylergometrine Organisms Affected

Humans and other mammals