Methergin Brand names, Methergin Analogs
Methergin Brand Names Mixture
Methergin fda sheet
Methergin msds (material safety sheet)
Methergin Synthesis Reference
A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)
Methergin Molecular Weight
Methergin Melting Point
Methergin H2O Solubility
Methergin Dosage Forms
Injection (intramuscular or intravenous); Tablet
For the prevention and control of excessive bleeding following vaginal childbirth
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.
Methergin side effects and Toxicity
Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.
Methergin Patient Information
Methergin Organisms Affected
Humans and other mammals