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Methergin
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Methergin Brand names, Methergin Analogs

Methergin Brand Names Mixture

  • No information avaliable

Methergin Chemical_Formula

C20H25N3O2

Methergin RX_link

http://www.rxlist.com/cgi/generic2/methylerg.htm

Methergin fda sheet

Methergin msds (material safety sheet)

Methergin MSDS

Methergin Synthesis Reference

A. Stoll et al., eidem, Helv. Chim. Acta. 26, 944 (1943)

Methergin Molecular Weight

339.432 g/mol

Methergin Melting Point

172 oC

Methergin H2O Solubility

25 mg/mL

Methergin State

Solid

Methergin LogP

1.01

Methergin Dosage Forms

Injection (intramuscular or intravenous); Tablet

Methergin Indication

For the prevention and control of excessive bleeding following vaginal childbirth

Methergin Pharmacology

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Methergin Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Methergin side effects and Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methergin Patient Information

Methergin Organisms Affected

Humans and other mammals