Fluxum
Category
Fluxum Brand names, Fluxum Analogs
Fluxum Brand Names Mixture
Fluxum Chemical_Formula
(C26H40N2O36S5)n
Fluxum RX_link
http://www.rxlist.com/cgi/generic/heparin.htm
Fluxum fda sheet
Fluxum msds (material safety sheet)
Fluxum Synthesis Reference
No information avaliable
Fluxum Molecular Weight
12000-15000 g/mol
Fluxum Melting Point
No information avaliable
Fluxum H2O Solubility
Soluble
Fluxum State
Solid
Fluxum LogP
No information avaliable
Fluxum Dosage Forms
Solution for subcutaneous injection; Intravenous injection; Intravenous infusion
Fluxum Indication
For anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension, for prevention of post-operative deep venous thrombosis and pulmonary embolism and for the prevention of clotting in arterial and cardiac surgery.
Fluxum Pharmacology
Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Heparin is a well known and commonly used anticoagulant which has antithrombotic properties. Heparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin III (Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Fluxum Absorption
Some oral absorption but lack of anticoagulant effect. Rapidly taken up by endothelial cells with remainder bound to plasma proteins.
Fluxum side effects and Toxicity
Heparin sodium - Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors
Fluxum Patient Information
No information avaliable
Fluxum Organisms Affected
Humans and other mammals
