Heparin sodium salt
Category
Heparin sodium salt Brand names, Heparin sodium salt Analogs
Heparin sodium salt Brand Names Mixture
Heparin sodium salt Chemical_Formula
(C26H40N2O36S5)n
Heparin sodium salt RX_link
http://www.rxlist.com/cgi/generic/heparin.htm
Heparin sodium salt fda sheet
Heparin sodium salt msds (material safety sheet)
Heparin sodium salt Synthesis Reference
No information avaliable
Heparin sodium salt Molecular Weight
12000-15000 g/mol
Heparin sodium salt Melting Point
No information avaliable
Heparin sodium salt H2O Solubility
Soluble
Heparin sodium salt State
Solid
Heparin sodium salt LogP
No information avaliable
Heparin sodium salt Dosage Forms
Solution for subcutaneous injection; Intravenous injection; Intravenous infusion
Heparin sodium salt Indication
For anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension, for prevention of post-operative deep venous thrombosis and pulmonary embolism and for the prevention of clotting in arterial and cardiac surgery.
Heparin sodium salt Pharmacology
Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Heparin is a well known and commonly used anticoagulant which has antithrombotic properties. Heparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin III (Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Heparin sodium salt Absorption
Some oral absorption but lack of anticoagulant effect. Rapidly taken up by endothelial cells with remainder bound to plasma proteins.
Heparin sodium salt side effects and Toxicity
Heparin sodium - Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors
Heparin sodium salt Patient Information
No information avaliable
Heparin sodium salt Organisms Affected
Humans and other mammals
