Pabyrin
Category
Pabyrin Brand names, Pabyrin Analogs
Pabyrin Brand Names Mixture
Pabyrin Chemical_Formula
(C26H40N2O36S5)n
Pabyrin RX_link
http://www.rxlist.com/cgi/generic/heparin.htm
Pabyrin fda sheet
Pabyrin msds (material safety sheet)
Pabyrin Synthesis Reference
No information avaliable
Pabyrin Molecular Weight
12000-15000 g/mol
Pabyrin Melting Point
No information avaliable
Pabyrin H2O Solubility
Soluble
Pabyrin State
Solid
Pabyrin LogP
No information avaliable
Pabyrin Dosage Forms
Solution for subcutaneous injection; Intravenous injection; Intravenous infusion
Pabyrin Indication
For anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension, for prevention of post-operative deep venous thrombosis and pulmonary embolism and for the prevention of clotting in arterial and cardiac surgery.
Pabyrin Pharmacology
Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Heparin is a well known and commonly used anticoagulant which has antithrombotic properties. Heparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin III (Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Pabyrin Absorption
Some oral absorption but lack of anticoagulant effect. Rapidly taken up by endothelial cells with remainder bound to plasma proteins.
Pabyrin side effects and Toxicity
Heparin sodium - Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors
Pabyrin Patient Information
No information avaliable
Pabyrin Organisms Affected
Humans and other mammals
