Cyclobenz Brand names, Cyclobenz Analogs
Cyclobenz Brand Names Mixture
Cyclobenz fda sheet
Cyclobenz msds (material safety sheet)
Cyclobenz Synthesis Reference
Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)
Cyclobenz Molecular Weight
Cyclobenz Melting Point
216-218 oC (HCl salt)
Cyclobenz H2O Solubility
Cyclobenz Dosage Forms
Tablet (5 mg, 10 mg)
For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.
Slowly but well absorbed after oral administration
Cyclobenz side effects and Toxicity
Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.
Cyclobenz Patient Information
FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or
physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor
vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine,
with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg
dose and titrated slowly upward.
Cyclobenz Organisms Affected
Humans and other mammals