Cyclobenzaprine HCL
Cyclobenzaprine HCL Brand names, Cyclobenzaprine HCL Analogs
Cyclobenzaprine HCL Brand Names Mixture
- No information avaliable
Cyclobenzaprine HCL Chemical_Formula
C20H21N
Cyclobenzaprine HCL RX_link
http://www.rxlist.com/cgi/generic/cyclobnz.htm
Cyclobenzaprine HCL fda sheet
Cyclobenzaprine HCL msds (material safety sheet)
Cyclobenzaprine HCL Synthesis Reference
Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)
Cyclobenzaprine HCL Molecular Weight
275.387 g/mol
Cyclobenzaprine HCL Melting Point
216-218 oC (HCl salt)
Cyclobenzaprine HCL H2O Solubility
Freely Soluble
Cyclobenzaprine HCL State
Solid
Cyclobenzaprine HCL LogP
4.974
Cyclobenzaprine HCL Dosage Forms
Tablet (5 mg, 10 mg)
Cyclobenzaprine HCL Indication
For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Cyclobenzaprine HCL Pharmacology
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.
Cyclobenzaprine HCL Absorption
Slowly but well absorbed after oral administration
Cyclobenzaprine HCL side effects and Toxicity
Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.
Cyclobenzaprine HCL Patient Information
FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.
Cyclobenzaprine HCL Organisms Affected
Humans and other mammals
