Flexeril en es it fr

Flexeril Brand names, Flexeril Analogs

Flexeril Brand Names Mixture

  • No information avaliable

Flexeril Chemical_Formula


Flexeril RX_link


Flexeril fda sheet

Flexeril FDA

Flexeril msds (material safety sheet)

Flexeril Synthesis Reference

Villani et al.; J. Org. Med. Pharm. Chem. 5, 373 (1962)

Flexeril Molecular Weight

275.387 g/mol

Flexeril Melting Point

216-218 oC (HCl salt)

Flexeril H2O Solubility

Freely Soluble

Flexeril State


Flexeril LogP


Flexeril Dosage Forms

Tablet (5 mg, 10 mg)

Flexeril Indication

For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Flexeril Pharmacology

Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.

Flexeril Absorption

Slowly but well absorbed after oral administration

Flexeril side effects and Toxicity

Oral mouse and rat LD50 are 338 mg/kg and 425 mg/kg respectively. Signs of overdose include agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low temperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, and vomiting.

Flexeril Patient Information

FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

Flexeril Organisms Affected

Humans and other mammals