Cetrorelix acetate
Category
Cetrorelix acetate Brand names, Cetrorelix acetate Analogs
Cetrorelix acetate Brand Names Mixture
Cetrorelix acetate Chemical_Formula
No information avaliable
Cetrorelix acetate RX_link
http://www.rxlist.com/cgi/generic2/cetrorelix.htm
Cetrorelix acetate fda sheet
Cetrorelix acetate msds (material safety sheet)
Cetrorelix acetate Synthesis Reference
No information avaliable
Cetrorelix acetate Molecular Weight
1431.06 g/mol
Cetrorelix acetate Melting Point
No information avaliable
Cetrorelix acetate H2O Solubility
No information avaliable
Cetrorelix acetate State
Solid
Cetrorelix acetate LogP
No information avaliable
Cetrorelix acetate Dosage Forms
Powder for solution
Cetrorelix acetate Indication
For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation.
Cetrorelix acetate Pharmacology
Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
Cetrorelix acetate Absorption
Rapidly absorbed following subcutaneous injection. The mean absolute bioavailability following subcutaneous administration to healthy female subjects is 85%.
Cetrorelix acetate side effects and Toxicity
No information avaliable
Cetrorelix acetate Patient Information
Cetrorelix acetate Organisms Affected
Humans and other mammals
