Butoconazole_nitrate
Category
Butoconazole_nitrate Brand names, Butoconazole_nitrate Analogs
Butoconazole_nitrate Brand Names Mixture
No information avaliable
Butoconazole_nitrate Chemical_Formula
C19H17Cl3N2S
Butoconazole_nitrate RX_link
http://www.rxlist.com/cgi/generic2/butoconazole.htm
Butoconazole_nitrate fda sheet
Butoconazole_nitrate msds (material safety sheet)
Butoconazole_nitrate Synthesis Reference
No information avaliable
Butoconazole_nitrate Molecular Weight
411.776 g/mol
Butoconazole_nitrate Melting Point
Melts at about 159°C with decomposition (nitrate salt)
Butoconazole_nitrate H2O Solubility
Nitrate salt: 0.26 mg/ml (practically insoluble)
Butoconazole_nitrate State
Solid
Butoconazole_nitrate LogP
6.512
Butoconazole_nitrate Dosage Forms
Vaginal cream (2%)
Butoconazole_nitrate Indication
For the local treatment of vulvovaginal candidiasis (infections caused by Candida)
Butoconazole_nitrate Pharmacology
Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.
Butoconazole_nitrate Absorption
Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.
Butoconazole_nitrate Toxicity
Oral, rat: LD50 = >1720 mg/kg.
Butoconazole_nitrate Patient Information
Butoconazole_nitrate Organisms Affected
Fungi, yeast and protozoans
