Butoconazolum_[INN-Latin]

Category

Butoconazolum_[INN-Latin]




Useful info

Butoconazolum_[INN-Latin] Brand names, Butoconazolum_[INN-Latin] Analogs

Butoconazolum_[INN-Latin] Brand Names Mixture

  • No information avaliable

    • Butoconazolum_[INN-Latin] Chemical_Formula

    C19H17Cl3N2S

    Butoconazolum_[INN-Latin] RX_link

    http://www.rxlist.com/cgi/generic2/butoconazole.htm

    Butoconazolum_[INN-Latin] fda sheet

    Butoconazolum_[INN-Latin] FDA

    Butoconazolum_[INN-Latin] msds (material safety sheet)

    Butoconazolum_[INN-Latin] MSDS

    Butoconazolum_[INN-Latin] Synthesis Reference

    No information avaliable

    Butoconazolum_[INN-Latin] Molecular Weight

    411.776 g/mol

    Butoconazolum_[INN-Latin] Melting Point

    Melts at about 159°C with decomposition (nitrate salt)

    Butoconazolum_[INN-Latin] H2O Solubility

    Nitrate salt: 0.26 mg/ml (practically insoluble)

    Butoconazolum_[INN-Latin] State

    Solid

    Butoconazolum_[INN-Latin] LogP

    6.512

    Butoconazolum_[INN-Latin] Dosage Forms

    Vaginal cream (2%)

    Butoconazolum_[INN-Latin] Indication

    For the local treatment of vulvovaginal candidiasis (infections caused by Candida)

    Butoconazolum_[INN-Latin] Pharmacology

    Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.

    Butoconazolum_[INN-Latin] Absorption

    Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.

    Butoconazolum_[INN-Latin] Toxicity

    Oral, rat: LD50 = >1720 mg/kg.

    Butoconazolum_[INN-Latin] Patient Information

    Butoconazolum_[INN-Latin] Organisms Affected

    Fungi, yeast and protozoans